Peptide Comparisons

BPC-157 is better researched for localized tissue injuries, tendons, ligaments, and GI tract issues. TB-500 distributes more systemically and shows stronger research for cardiac and widespread inflammatory conditions. For targeted musculoskeletal injuries, BPC-157 has more supporting data. For systemic recovery needs, TB-500 may offer broader reach. Many research protocols use both together.

Tirzepatide produces greater average weight loss and A1C reduction in clinical trials, with the SURPASS-2 trial showing statistical superiority over semaglutide. However, semaglutide has a longer track record, more real-world safety data, and an oral formulation option. Both are highly effective. The choice often comes down to insurance coverage, availability, and individual response patterns.

CJC-1295 provides stronger, more sustained GH elevation and is better for protocols prioritizing total GH output and IGF-1 increases. Ipamorelin is the cleaner, more selective option with fewer side effects and a more natural GH pulse pattern. They work through different receptors, which is why many protocols use them together as a stack for complementary effects.

Selank is the better choice for researchers studying anxiety-related cognitive impairment, offering calm focus without stimulation. Semax is superior for pure cognitive enhancement, neuroprotection, and BDNF-related research, providing a more stimulating nootropic profile. The choice depends on whether the research priority is reducing cognitive interference from anxiety (Selank) or directly enhancing neural function (Semax).

Melanotan I is the safer, more selective option specifically for melanogenesis research, with actual clinical approval. Melanotan II produces stronger tanning effects and has additional sexual function and appetite applications, but comes with more side effects due to its non-selective receptor activation. For pure melanin research, MT-I is more appropriate. For multi-target research, MT-II covers more ground.

GHRP-2 produces more GH per dose with fewer appetite-related side effects, making it better for research focused purely on GH output. GHRP-6 is the choice when appetite stimulation is desired alongside GH release, or when cost is a primary consideration. Both have been largely superseded by Ipamorelin for protocols prioritizing minimal side effects.

Sermorelin is the more physiological choice, it acts identically to your body's own GHRH and preserves natural pulsatile GH release. CJC-1295 is significantly more potent and convenient, especially the DAC variant with weekly dosing. Choose Sermorelin for research prioritizing natural GH patterns; choose CJC-1295 for maximum GH output and dosing convenience.

Semaglutide is the proven choice with FDA approval, cardiovascular outcome data, and years of real-world experience. Retatrutide shows superior weight loss in early trials (24% vs 17%), with the triple-receptor mechanism potentially addressing limitations of GLP-1-only approaches. However, retatrutide remains experimental. For current research, semaglutide is the validated standard; retatrutide is the promising future that still needs Phase III confirmation.

GHK-Cu is better for targeted tissue repair, wound healing, and cosmetic applications where direct copper delivery enhances remodeling. Free GHK is more interesting for systemic anti-aging and gene expression research. For skin rejuvenation and wound studies, GHK-Cu has more direct evidence. For broad anti-aging mechanisms and gene resetting research, GHK's genome-wide effects are more compelling.

Epithalon targets a deeper, more fundamental aging mechanism (telomere maintenance) but has a narrower evidence base concentrated in Russian research. GHK-Cu has broader, more internationally validated research across tissue repair and gene expression, but its anti-aging effects are more distributed and arguably more surface-level. For fundamental aging biology research, Epithalon is more intriguing. For practical tissue rejuvenation with broader evidence, GHK-Cu is stronger.

For musculoskeletal injuries (tendons, ligaments, muscle) and GI tract repair, BPC-157 has significantly more supporting research. For skin wounds, cosmetic rejuvenation, and surface tissue remodeling, GHK-Cu is the stronger choice. They operate in complementary tissue compartments with minimal overlap, making them a logical combination for protocols addressing both internal and surface tissue repair.