Adipotide
Also known as: CKGGRAKDC-GG-D(KLAKLAK)2, Prohibitin Targeting Peptide
Adipotide is an experimental peptide compound designed to selectively target and destroy blood vessels that supply white adipose tissue. This mechanism causes fat cell death by cutting off their blood supply, leading to rapid fat loss in research models.
Adipotide is a 2,611 Da research peptide. Adipotide is an experimental peptide compound designed to selectively target and destroy blood vessels that supply white adipose tissue. This mechanism causes fat cell death by cutting off their blood supply, leading to rapid fat loss in research models.
Also called: CKGGRAKDC-GG-D(KLAKLAK)2, Prohibitin Targeting Peptide
2,611
Molecular Weight
Daltons
0
Strong Evidence
benefits
4
Studies Cited
peer-reviewed
1-5
Typical Dose
mg/kg
Overview
Adipotide represents a novel approach to fat reduction through targeted vascular destruction. The peptide consists of two functional domains: a prohibitin-targeting sequence (CKGGRAKDC) that binds specifically to blood vessels in white fat tissue, and a pro-apoptotic sequence (KLAKLAK)2 that triggers cell death. When Adipotide binds to prohibitin receptors on fat tissue vasculature, it disrupts mitochondrial function and initiates apoptosis in endothelial cells. This causes the blood vessels feeding fat cells to collapse, leading to ischemia and subsequent adipocyte death. The peptide demonstrates selectivity for white adipose tissue over other organs, though this selectivity is not absolute. Research in animal models shows dramatic weight loss effects, but human studies remain limited due to safety concerns.
Key Takeaways: Adipotide
- Research doses typically range from 1 to 5 mg/kg via subcutaneous
- 0 benefits with strong evidence, 2 moderate, 4 preliminary
- Half-life: 2-4 hours
- 4 cited research studies in this guide
Mechanism of Action
Adipotide binds to prohibitin receptors on blood vessel walls within white adipose tissue. The prohibitin-targeting domain (CKGGRAKDC) provides tissue specificity, while the (KLAKLAK)2 domain disrupts mitochondrial membranes in endothelial cells. This dual mechanism causes selective apoptosis of fat tissue vasculature, leading to blood vessel collapse, tissue ischemia, and subsequent fat cell death. The process triggers an inflammatory response that helps clear dead tissue.
Research Benefits
Adipotide at a Glance
Adipotide binds to prohibitin receptors on blood vessel walls within white adipose tissue.
Rapid Fat Loss
Moderate EvidenceCauses dramatic weight reduction by destroying fat tissue blood supply. Animal studies show 20-30% body weight loss within weeks of treatment.
Targeted White Adipose Tissue
Moderate EvidenceDemonstrates preferential binding to white fat blood vessels compared to other tissues, though selectivity is not complete.
Preserved Lean Mass
PreliminaryResearch models show fat loss occurs with minimal impact on muscle tissue when compared to caloric restriction alone.
Metabolic Improvements
PreliminarySecondary metabolic benefits including improved insulin sensitivity and glucose tolerance following fat mass reduction.
Visceral Fat Reduction
PreliminaryAppears to target both subcutaneous and visceral fat deposits, potentially reducing metabolic disease risk factors.
Sustained Weight Loss
PreliminaryWeight loss effects persist for extended periods after treatment cessation in animal models.
Research Dosing Protocols
Research Purposes Only: All content is for informational and research purposes only. This site does not provide medical advice, diagnosis, or treatment. Consult a qualified healthcare professional before using any peptide or supplement.
| Research Protocol | Dose Range | Route |
|---|---|---|
| Fat loss research | 1–5 mg/kg | subcutaneous |
| Toxicity studies | 0.1–1 mg/kg | intraperitoneal |
Frequency
Every 48-72 hours
Timing
No specific timing requirements
Cycle Length
2-4 weeks maximum
Research Notes
- 1Extremely dangerous compound - multiple deaths reported in research
- 2Requires careful dose escalation and monitoring
- 3Not approved for human use anywhere
- 4Research use only under strict laboratory conditions
Reconstitution Guide
Standard Reconstitution
Vial Size
2 mg
Bacteriostatic Water
2 mL
Concentration
10 mcg
per 0.1 mL (10 units)
Step-by-Step Guide
Gather Materials
Adipotide vial, bacteriostatic water, alcohol swabs, insulin syringes.
Equilibrate Temperature
Remove the vial from storage and allow it to reach room temperature (5-10 minutes).
Sanitize
Swab the rubber stopper of both the peptide vial and bacteriostatic water vial with alcohol.
Draw Water
Draw 2 mL of bacteriostatic water into a syringe.
Add Water to Vial
Insert the needle into the peptide vial and direct the water stream against the glass wall — not directly onto the powder.
Mix Gently
Swirl the vial gently until the powder is fully dissolved. Never shake. The solution should be clear and colorless.
Store Properly
Refrigerate at 2-8°C. 30 days refrigerated.
Storage Temperature
2-8°C
Shelf Life
30 days refrigerated
Important Notes
- •Handle with extreme caution due to toxicity
- •Use bacteriostatic water for reconstitution
- •Store away from light
- •Dispose of properly - do not flush or discard casually
Adipotide Dosing Calculator
Calculate daily intake, cycle totals, and vials needed with pre-filled protocols →
Adipotide Reconstitution Calculator
Calculate concentration, syringe units, and doses per vial with auto-filled values →
Safety & Side Effects
Reported Side Effects
- !Severe dehydration from rapid fat tissue breakdown
- !Electrolyte imbalances and metabolic acidosis
- !Kidney damage from tissue breakdown products
- !Liver toxicity and elevated liver enzymes
- !Extreme fatigue and weakness
- !Nausea and gastrointestinal distress
- !Skin necrosis at injection sites
- !Potential organ damage from non-specific targeting
- !Death from multi-organ failure
- !Immune system dysfunction
Potential Interactions
- ⚡Blood thinners may increase bleeding risk
- ⚡Diuretics may worsen dehydration
- ⚡Nephrotoxic drugs increase kidney damage risk
- ⚡Hepatotoxic medications compound liver stress
- ⚡Other weight loss drugs may cause dangerous interactions
Important: Side effects and interactions listed here are compiled from published research and community reports. This is not a complete list. No formal drug interaction studies have been conducted for most research peptides. Always consult a qualified healthcare provider.
Research Studies
The following studies are referenced in this profile. PubMed IDs are provided where available for independent verification.
A peptidomimetic targeting white fat causes apoptosis of adipose endothelial cells and massive weight loss in obese mice
First demonstration that Adipotide causes selective apoptosis in white adipose tissue vasculature, resulting in significant weight loss in obese mice.
Reversal of obesity by targeted ablation of adipose tissue
Confirmed Adipotide's mechanism and effectiveness in primate models, but highlighted significant safety concerns including renal toxicity.
Safety evaluation of adipotide in non-human primates
Detailed toxicity study revealing dose-dependent organ damage and establishing maximum tolerated doses in primate models.
Prohibitin targeting peptides for obesity treatment
Review of Adipotide's development, mechanism of action, and the challenges preventing clinical translation due to safety profile.
Note: This is not an exhaustive list of all published research. Studies are selected for relevance and quality. Click PubMed IDs to verify sources independently. Inclusion does not imply endorsement of the peptide for any clinical use.
Frequently Asked Questions
No, Adipotide is extremely dangerous and has caused multiple deaths. It is not approved for human use anywhere and should only be handled by qualified researchers under strict laboratory conditions.
Animal studies show 20-30% body weight loss within weeks, but this comes with severe toxicity including organ damage and death. These results cannot be extrapolated to humans safely.
Adipotide is available only to licensed research institutions. It is illegal for human consumption and extremely dangerous to handle without proper training and safety equipment.
Side effects include severe dehydration, organ damage, kidney failure, liver toxicity, and death. The peptide destroys blood vessels indiscriminately, causing unpredictable tissue damage.
Adipotide destroys blood vessels feeding fat tissue by binding to prohibitin receptors and triggering cell death. This cuts off blood supply to fat cells, causing them to die from lack of oxygen and nutrients.
No peptide offers similar rapid fat loss effects. Safer research peptides like AOD-9604 or CJC-1295 provide modest metabolic benefits without the extreme risks of Adipotide.
Adipotide affects fat tissue systemically and cannot target specific areas. It shows some preference for white adipose tissue but also damages other organs with similar blood vessel markers.
Weight loss effects persist for months in animal studies because the destroyed fat tissue takes time to regenerate. However, the health consequences may be permanent.
Research & Educational Use Only
All content is for informational and research purposes only. This site does not provide medical advice, diagnosis, or treatment. Consult a qualified healthcare professional before using any peptide or supplement.
The information presented here is compiled from published research studies and is intended for informational purposes only. Individual results may vary. Always consult with a licensed healthcare provider.