Angiotensin 1-7
Also known as: Ang(1-7), A(1-7), Angiotensin-(1-7)
Angiotensin 1-7 is an endogenous heptapeptide that functions as a counter-regulatory component of the renin-angiotensin system, promoting vasodilation and cardioprotective effects through MAS receptor activation.
Angiotensin 1-7 is a 899.0 g/mol research peptide. Angiotensin 1-7 is an endogenous heptapeptide that functions as a counter-regulatory component of the renin-angiotensin system, promoting vasodilation and cardioprotective effects through MAS receptor activation.
Also called: Ang(1-7), A(1-7), Angiotensin-(1-7)
899.0 g/mol
Molecular Weight
Daltons
2
Strong Evidence
benefits
5
Studies Cited
peer-reviewed
10-100
Typical Dose
μg/kg/day
Overview
Angiotensin 1-7 represents a crucial component of the protective arm of the renin-angiotensin system (RAS), acting as a direct physiological antagonist to the vasoconstricting effects of angiotensin II. This naturally occurring heptapeptide is generated through the enzymatic cleavage of angiotensin II by angiotensin-converting enzyme 2 (ACE2) or from angiotensin I via neutral endopeptidase and thimet oligopeptidase. The peptide exerts its beneficial cardiovascular effects primarily through binding to the MAS receptor, a G-protein coupled receptor that mediates vasodilation, anti-inflammatory responses, and cardioprotective signaling pathways. Research indicates that Ang(1-7) plays a significant role in maintaining cardiovascular homeostasis by opposing the detrimental effects of excessive angiotensin II activation, including hypertension, cardiac remodeling, and vascular inflammation. The peptide has shown promise in experimental models of heart failure, hypertension, and diabetic complications, making it an important target for therapeutic intervention. Its unique mechanism of action through the ACE2/Ang(1-7)/MAS axis has positioned it as a potential treatment for conditions where the traditional RAS system is overactivated.
Key Takeaways: Angiotensin 1-7
- Strongest evidence supports Angiotensin 1-7 for blood pressure reduction and cardioprotective effects
- Research doses typically range from 10 to 100 μg/kg/day via subcutaneous infusion
- 2 benefits with strong evidence, 3 moderate, 2 preliminary
- Half-life: 12-20 seconds in plasma
- 5 cited research studies in this guide
Mechanism of Action
Angiotensin 1-7 binds selectively to the MAS receptor (MRGPRD), activating downstream signaling pathways that promote vasodilation through nitric oxide and prostacyclin release. The peptide activates protein kinase A and Akt pathways while inhibiting MAPK signaling, resulting in anti-inflammatory, anti-fibrotic, and cardioprotective effects. It also modulates ion channels and promotes endothelial function through eNOS activation.
Research Benefits
Angiotensin 1-7 at a Glance
Angiotensin 1-7 binds selectively to the MAS receptor (MRGPRD), activating downstream signaling pathways that promote vasodilation through nitric oxide and prostacyclin release.
Blood Pressure Reduction
Strong EvidenceAng(1-7) produces significant vasodilation through MAS receptor-mediated nitric oxide release, leading to reduced peripheral vascular resistance and lowered blood pressure in hypertensive models.
Cardioprotective Effects
Strong EvidenceThe peptide prevents cardiac remodeling and reduces myocardial fibrosis by inhibiting collagen synthesis and promoting anti-inflammatory pathways in the heart tissue.
Endothelial Function Improvement
Moderate EvidenceAng(1-7) enhances endothelial nitric oxide synthase activity and promotes endothelial cell proliferation, improving overall vascular function and reducing atherosclerotic progression.
Anti-inflammatory Activity
Moderate EvidenceThe peptide reduces inflammatory cytokine production including TNF-α, IL-6, and IL-1β while promoting anti-inflammatory mediators, contributing to reduced vascular inflammation.
Renal Protection
Moderate EvidenceAng(1-7) demonstrates nephroprotective effects by reducing glomerular damage, proteinuria, and interstitial fibrosis in experimental models of kidney disease.
Metabolic Benefits
PreliminaryResearch suggests Ang(1-7) may improve insulin sensitivity and glucose metabolism through modulation of adipose tissue function and inflammatory pathways.
Antiarrhythmic Properties
PreliminaryThe peptide shows potential in reducing cardiac arrhythmias by stabilizing membrane potentials and modulating calcium handling in cardiac myocytes.
Research Dosing Protocols
Research Purposes Only: All content is for informational and research purposes only. This site does not provide medical advice, diagnosis, or treatment. Consult a qualified healthcare professional before using any peptide or supplement.
| Research Protocol | Dose Range | Route |
|---|---|---|
| Cardiovascular research | 10–100 μg/kg/day | subcutaneous infusion |
| Blood pressure studies | 0.1–1 mg/kg/day | intravenous infusion |
| Cardiac remodeling research | 24–144 μg/day | osmotic pump |
Frequency
Continuous infusion preferred due to short half-life
Timing
Administered via osmotic pumps or continuous IV infusion
Cycle Length
Study duration typically 2-8 weeks
Research Notes
- 1Extremely short plasma half-life requires continuous administration
- 2Oral administration ineffective due to rapid peptidase degradation
- 3Modified analogs with longer half-lives under development
- 4Dose adjustments needed based on baseline blood pressure
Reconstitution Guide
Standard Reconstitution
Vial Size
1 mg
Bacteriostatic Water
1 mL
Concentration
10 mcg
per 0.1 mL (10 units)
Step-by-Step Guide
Gather Materials
Angiotensin 1-7 vial, bacteriostatic water, alcohol swabs, insulin syringes.
Equilibrate Temperature
Remove the vial from storage and allow it to reach room temperature (5-10 minutes).
Sanitize
Swab the rubber stopper of both the peptide vial and bacteriostatic water vial with alcohol.
Draw Water
Draw 1 mL of bacteriostatic water into a syringe.
Add Water to Vial
Insert the needle into the peptide vial and direct the water stream against the glass wall — not directly onto the powder.
Mix Gently
Swirl the vial gently until the powder is fully dissolved. Never shake. The solution should be clear and colorless.
Store Properly
Refrigerate at 2-8°C. 24-48 hours after reconstitution.
Storage Temperature
2-8°C
Shelf Life
24-48 hours after reconstitution
Important Notes
- •Use sterile water or saline for reconstitution
- •Peptide extremely unstable in solution
- •Prepare fresh solutions for each administration
- •Consider peptidase inhibitors to extend stability
- •Store lyophilized powder at -20°C or below
Angiotensin 1-7 Dosing Calculator
Calculate daily intake, cycle totals, and vials needed with pre-filled protocols →
Angiotensin 1-7 Reconstitution Calculator
Calculate concentration, syringe units, and doses per vial with auto-filled values →
Safety & Side Effects
Reported Side Effects
- !Hypotension and dizziness
- !Fatigue and weakness
- !Headache
- !Nausea
- !Injection site reactions (if applicable)
- !Electrolyte imbalances
- !Potential hyperkalemia
- !Renal function changes
- !Orthostatic hypotension
- !Bradycardia
Potential Interactions
- ⚡ACE inhibitors may enhance hypotensive effects
- ⚡ARBs could potentiate blood pressure lowering
- ⚡Diuretics may increase risk of hypotension
- ⚡NSAIDs may reduce cardiovascular benefits
- ⚡Beta-blockers could amplify bradycardic effects
Important: Side effects and interactions listed here are compiled from published research and community reports. This is not a complete list. No formal drug interaction studies have been conducted for most research peptides. Always consult a qualified healthcare provider.
Research Studies
The following studies are referenced in this profile. PubMed IDs are provided where available for independent verification.
Angiotensin-(1-7) prevents cardiac remodeling in rats with hypertension
Demonstrated that Ang(1-7) infusion prevented left ventricular hypertrophy and improved diastolic function in spontaneously hypertensive rats through MAS receptor activation.
Angiotensin-(1-7) induces vasodilation in human coronary arteries
Clinical study showing direct vasodilatory effects of Ang(1-7) in isolated human coronary arteries, mediated by nitric oxide and prostacyclin release.
Protective role of angiotensin-(1-7) in diabetic nephropathy
Research demonstrating nephroprotective effects of Ang(1-7) in diabetic kidney disease models, reducing proteinuria and glomerular damage.
Angiotensin-(1-7) attenuates hypertension and heart failure
Study showing that chronic Ang(1-7) infusion reduced blood pressure and improved cardiac function in experimental heart failure models.
Anti-inflammatory effects of angiotensin-(1-7) in vascular disease
Investigation of Ang(1-7)'s anti-inflammatory properties, showing reduced cytokine production and improved endothelial function in atherosclerosis models.
Note: This is not an exhaustive list of all published research. Studies are selected for relevance and quality. Click PubMed IDs to verify sources independently. Inclusion does not imply endorsement of the peptide for any clinical use.
Frequently Asked Questions
Angiotensin 1-7 is primarily researched for cardiovascular applications including hypertension, heart failure, cardiac remodeling, and endothelial dysfunction. Studies also investigate its potential in diabetic complications and inflammatory conditions.
While angiotensin II promotes vasoconstriction and inflammation through AT1 receptors, angiotensin 1-7 produces opposite effects through MAS receptor activation, promoting vasodilation, anti-inflammatory responses, and cardioprotection.
Angiotensin 1-7 has extremely low oral bioavailability due to rapid degradation by peptidases in the digestive system. Its plasma half-life of 12-20 seconds requires continuous infusion for research applications.
Primary side effects include hypotension, dizziness, fatigue, and potential electrolyte imbalances. The peptide's blood pressure-lowering effects require careful monitoring during research protocols.
Due to its short half-life, Ang(1-7) is typically administered via continuous infusion using osmotic pumps or IV infusion rather than intermittent injections to maintain therapeutic levels.
Ang(1-7) may enhance the effects of ACE inhibitors, ARBs, and other antihypertensive medications, potentially causing excessive blood pressure reduction. Research protocols require careful dose adjustments.
The MAS receptor is a G-protein coupled receptor that mediates the beneficial effects of Ang(1-7), including vasodilation, anti-inflammatory responses, and cardioprotection, opposing the harmful effects of angiotensin II.
Reconstituted Ang(1-7) is extremely unstable with a shelf life of only 24-48 hours at 2-8°C. Fresh solutions should be prepared for each research application to ensure peptide integrity.
Research & Educational Use Only
All content is for informational and research purposes only. This site does not provide medical advice, diagnosis, or treatment. Consult a qualified healthcare professional before using any peptide or supplement.
The information presented here is compiled from published research studies and is intended for informational purposes only. Individual results may vary. Always consult with a licensed healthcare provider.