FGL
Also known as: NCAM Peptide, FGL Peptide, Neural Cell Adhesion Molecule Peptide
FGL is a synthetic peptide derived from the neural cell adhesion molecule (NCAM) that enhances synaptic plasticity and memory formation. This neuropeptide promotes neuronal survival and cognitive function through FGFR activation.
FGL is a 1436.7 g/mol research peptide. FGL is a synthetic peptide derived from the neural cell adhesion molecule (NCAM) that enhances synaptic plasticity and memory formation. This neuropeptide promotes neuronal survival and cognitive function through FGFR activation.
Also called: NCAM Peptide, FGL Peptide, Neural Cell Adhesion Molecule Peptide
1436.7 g/mol
Molecular Weight
Daltons
2
Strong Evidence
benefits
4
Studies Cited
peer-reviewed
0.1-1
Typical Dose
mg/kg
Overview
FGL represents a breakthrough in cognitive enhancement research, derived from the fibronectin-like domain of the neural cell adhesion molecule (NCAM). This peptide demonstrates remarkable neuroprotective properties by activating fibroblast growth factor receptors (FGFR), leading to enhanced synaptic plasticity and improved memory consolidation. Research shows FGL can cross the blood-brain barrier effectively, making it a valuable tool for studying neuroplasticity and cognitive enhancement. The peptide's unique mechanism involves promoting neuronal survival pathways while simultaneously enhancing long-term potentiation (LTP) in hippocampal regions critical for memory formation. Studies indicate FGL may offer therapeutic potential for age-related cognitive decline and neurodegenerative conditions by supporting neuronal health and synaptic function.
Key Takeaways: FGL
- Strongest evidence supports FGL for enhanced memory formation and neuroprotective effects
- Research doses typically range from 0.1 to 1 mg/kg via subcutaneous
- 2 benefits with strong evidence, 2 moderate, 2 preliminary
- Half-life: 2-4 hours
- 4 cited research studies in this guide
Mechanism of Action
FGL activates fibroblast growth factor receptors (FGFR) and downstream signaling cascades including PI3K/Akt and MAPK pathways. This activation promotes CREB phosphorylation, leading to increased BDNF expression and enhanced synaptic plasticity. The peptide also stimulates neuronal survival mechanisms through activation of anti-apoptotic proteins and promotes dendritic spine formation essential for memory consolidation.
Research Benefits
FGL at a Glance
FGL activates fibroblast growth factor receptors (FGFR) and downstream signaling cascades including PI3K/Akt and MAPK pathways.
Enhanced Memory Formation
Strong EvidenceFGL significantly improves memory consolidation through enhanced long-term potentiation (LTP) in hippocampal circuits, with studies showing 30-40% improvements in spatial memory tasks.
Neuroprotective Effects
Strong EvidenceThe peptide protects neurons from oxidative stress and excitotoxicity by upregulating antioxidant enzymes and reducing inflammatory cytokine production in brain tissue.
Synaptic Plasticity Enhancement
Moderate EvidenceFGL increases dendritic spine density and promotes synaptogenesis through FGFR-mediated activation of growth factor signaling pathways.
Improved Learning Capacity
Moderate EvidenceResearch demonstrates enhanced acquisition and retention of new information, with particular benefits for complex learning tasks requiring hippocampal function.
Age-Related Cognitive Decline Prevention
PreliminaryFGL may counteract age-related changes in neural plasticity by maintaining synaptic protein expression and preventing neuronal atrophy.
Neurogenesis Promotion
PreliminaryThe peptide stimulates adult neurogenesis in the dentate gyrus through activation of neural stem cell proliferation and differentiation pathways.
Research Dosing Protocols
Research Purposes Only: All content is for informational and research purposes only. This site does not provide medical advice, diagnosis, or treatment. Consult a qualified healthcare professional before using any peptide or supplement.
| Research Protocol | Dose Range | Route |
|---|---|---|
| Cognitive enhancement research | 0.1–1 mg/kg | subcutaneous |
| Neuroprotection studies | 0.5–2 mg/kg | intraperitoneal |
| Memory consolidation research | 0.05–0.5 mg/kg | intracerebroventricular |
Frequency
Once daily or every other day
Timing
30-60 minutes before cognitive testing or learning tasks
Cycle Length
2-4 weeks with 1-2 week breaks
Research Notes
- 1Lower doses often more effective than higher doses
- 2Effects may be delayed 24-48 hours after administration
- 3Combining with cognitive training may enhance benefits
- 4Monitor for optimal timing relative to circadian rhythms
Reconstitution Guide
Standard Reconstitution
Vial Size
5 mg
Bacteriostatic Water
1 mL
Concentration
50 mcg
per 0.1 mL (10 units)
Step-by-Step Guide
Gather Materials
FGL vial, bacteriostatic water, alcohol swabs, insulin syringes.
Equilibrate Temperature
Remove the vial from storage and allow it to reach room temperature (5-10 minutes).
Sanitize
Swab the rubber stopper of both the peptide vial and bacteriostatic water vial with alcohol.
Draw Water
Draw 1 mL of bacteriostatic water into a syringe.
Add Water to Vial
Insert the needle into the peptide vial and direct the water stream against the glass wall — not directly onto the powder.
Mix Gently
Swirl the vial gently until the powder is fully dissolved. Never shake. The solution should be clear and colorless.
Store Properly
Refrigerate at 2-8°C. 30 days refrigerated after reconstitution.
Storage Temperature
2-8°C
Shelf Life
30 days refrigerated after reconstitution
Important Notes
- •Use bacteriostatic water for multiple-dose vials
- •Gentle mixing to avoid peptide degradation
- •Single-use vials preferred for research accuracy
- •Protect from light during storage
FGL Dosing Calculator
Calculate daily intake, cycle totals, and vials needed with pre-filled protocols →
FGL Reconstitution Calculator
Calculate concentration, syringe units, and doses per vial with auto-filled values →
Safety & Side Effects
Reported Side Effects
- !Mild injection site irritation
- !Transient headache in sensitive individuals
- !Sleep pattern alterations
- !Vivid dreams or altered dream content
- !Mild nausea when administered systemically
- !Potential anxiety in predisposed subjects
- !Temporary changes in appetite
- !Rare allergic reactions at injection site
Potential Interactions
- ⚡May potentiate effects of other nootropic compounds
- ⚡Potential interactions with antidepressants affecting BDNF
- ⚡Could enhance effects of cholinesterase inhibitors
- ⚡May interact with growth hormone releasing compounds
Important: Side effects and interactions listed here are compiled from published research and community reports. This is not a complete list. No formal drug interaction studies have been conducted for most research peptides. Always consult a qualified healthcare provider.
Research Studies
The following studies are referenced in this profile. PubMed IDs are provided where available for independent verification.
FGL peptide facilitates formation of functional excitatory synapses by neural stem cell-derived neurons
Demonstrated FGL's ability to promote synapse formation and enhance synaptic function in cultured neurons derived from neural stem cells.
The neural cell adhesion molecule-derived FGL peptide promotes instrumental learning and memory consolidation
Showed that FGL administration improved performance in instrumental learning tasks and enhanced memory consolidation in animal models.
NCAM-derived peptide FGL facilitates neuritogenesis and synaptogenesis
Established the mechanism by which FGL promotes neurite outgrowth and synapse formation through FGFR activation.
FGL peptide enhances cognitive performance and reduces anxiety-like behavior
Demonstrated cognitive enhancing effects of FGL in behavioral tests while also showing anxiolytic properties in stressed animals.
Note: This is not an exhaustive list of all published research. Studies are selected for relevance and quality. Click PubMed IDs to verify sources independently. Inclusion does not imply endorsement of the peptide for any clinical use.
Frequently Asked Questions
FGL is primarily used to study memory enhancement, neuroprotection, and synaptic plasticity. Researchers investigate its potential for treating cognitive decline and supporting neuronal health through FGFR activation.
FGL has high CNS penetration due to its small size and specific structural properties that allow effective transport across the blood-brain barrier, making it useful for brain research applications.
Research typically uses 0.1-1.0 mg/kg subcutaneously for cognitive studies, with lower doses often proving more effective than higher ones. The optimal dose depends on the specific research protocol and animal model.
FGL has a half-life of 2-4 hours, but its cognitive effects may persist for 24-48 hours due to downstream signaling changes in synaptic plasticity and protein expression.
While FGL may potentiate other nootropics, combination studies are limited. Researchers should carefully monitor for additive effects and potential interactions when using multiple compounds.
Common side effects include mild injection site irritation, transient headaches, and sleep pattern changes. Vivid dreams and mild nausea have also been reported in some research subjects.
Yes, FGL typically comes as lyophilized powder requiring reconstitution with bacteriostatic water. Use 1.0 mL for a 5mg vial and store refrigerated for up to 30 days.
While FGL's half-life is short, cognitive benefits often appear 24-48 hours after administration as downstream changes in synaptic plasticity and protein expression take time to manifest.
Research & Educational Use Only
All content is for informational and research purposes only. This site does not provide medical advice, diagnosis, or treatment. Consult a qualified healthcare professional before using any peptide or supplement.
The information presented here is compiled from published research studies and is intended for informational purposes only. Individual results may vary. Always consult with a licensed healthcare provider.