Noopept
Also known as: N-Phenylacetyl-L-Prolylglycine Ethyl Ester, GVS-111
Noopept is a synthetic nootropic peptide that enhances cognitive function through AMPA receptor modulation and BDNF upregulation. Research shows it improves memory formation, learning capacity, and neuroprotection at doses 100-1000 times lower than traditional racetams.
Noopept is a 318.37 g/mol research peptide. Noopept is a synthetic nootropic peptide that enhances cognitive function through AMPA receptor modulation and BDNF upregulation. Research shows it improves memory formation, learning capacity, and neuroprotection at doses 100-1000 times lower than traditional racetams.
Also called: N-Phenylacetyl-L-Prolylglycine Ethyl Ester, GVS-111
318.37 g/mol
Molecular Weight
Daltons
2
Strong Evidence
benefits
4
Studies Cited
peer-reviewed
10-30
Typical Dose
mg
Overview
Noopept represents a breakthrough in synthetic nootropic compounds, offering potent cognitive enhancement through multiple neurochemical pathways. This dipeptide analog crosses the blood-brain barrier efficiently and metabolizes into cycloprolylglycine, which drives its primary effects on glutamatergic neurotransmission. Unlike traditional racetams, Noopept demonstrates activity at microdoses while providing comprehensive neuroprotective benefits. The compound enhances both short-term working memory and long-term memory consolidation through AMPA receptor sensitization and increased brain-derived neurotrophic factor expression. Research applications focus on memory disorders, cognitive decline, and neuroplasticity enhancement protocols.
Key Takeaways: Noopept
- Strongest evidence supports Noopept for memory enhancement and learning acceleration
- Research doses typically range from 10 to 30 mg via oral
- 2 benefits with strong evidence, 3 moderate, 2 preliminary
- Half-life: 25-30 minutes
- 4 cited research studies in this guide
Mechanism of Action
Noopept functions as an AMPA receptor positive allosteric modulator, increasing glutamate sensitivity without direct receptor binding. The active metabolite cycloprolylglycine upregulates BDNF and NGF expression, promoting synaptic plasticity and neurogenesis. Additional mechanisms include acetylcholine esterase inhibition, enhanced calcium-dependent protein kinase II activity, and modulation of voltage-gated calcium channels. These pathways collectively improve synaptic transmission efficiency and long-term potentiation.
Research Benefits
Noopept at a Glance
Noopept functions as an AMPA receptor positive allosteric modulator, increasing glutamate sensitivity without direct receptor binding.
Memory Enhancement
Strong EvidenceImproves both working memory and long-term memory consolidation through AMPA receptor modulation and increased synaptic plasticity.
Learning Acceleration
Strong EvidenceEnhances acquisition of new information and skill learning by optimizing glutamatergic neurotransmission and BDNF signaling.
Neuroprotection
Moderate EvidenceProtects neurons from oxidative stress and excitotoxicity while promoting neuronal survival through growth factor upregulation.
Cognitive Recovery
Moderate EvidenceAccelerates cognitive function restoration following brain injury or neurological insults by supporting neuroplasticity mechanisms.
Attention and Focus
Moderate EvidenceImproves sustained attention and cognitive control through enhanced prefrontal cortex function and neurotransmitter balance.
Anxiety Reduction
PreliminaryDemonstrates anxiolytic effects independent of sedation, potentially through GABA system modulation and stress hormone regulation.
Cerebral Blood Flow
PreliminaryIncreases regional cerebral blood flow and oxygen utilization, supporting optimal brain metabolism and function.
Research Dosing Protocols
Research Purposes Only: All content is for informational and research purposes only. This site does not provide medical advice, diagnosis, or treatment. Consult a qualified healthcare professional before using any peptide or supplement.
| Research Protocol | Dose Range | Route |
|---|---|---|
| General cognitive enhancement | 10–30 mg | oral |
| Memory research | 20–40 mg | oral |
| Neuroprotection studies | 30–60 mg | oral |
Frequency
1-2 times daily
Timing
Morning and early afternoon with or without food
Cycle Length
8-12 weeks with 2-4 week breaks
Research Notes
- 1Start with lowest effective dose due to high potency
- 2Effects may accumulate over several days of consistent use
- 3Avoid evening doses due to potential sleep disruption
- 4Sublingual administration may increase bioavailability
Reconstitution Guide
Standard Reconstitution
Vial Size
0 mg
Bacteriostatic Water
0 mL
Concentration
NaN mcg
per 0.1 mL (10 units)
Step-by-Step Guide
Gather Materials
Noopept vial, bacteriostatic water, alcohol swabs, insulin syringes.
Equilibrate Temperature
Remove the vial from storage and allow it to reach room temperature (5-10 minutes).
Sanitize
Swab the rubber stopper of both the peptide vial and bacteriostatic water vial with alcohol.
Draw Water
Draw 0 mL of bacteriostatic water into a syringe.
Add Water to Vial
Insert the needle into the peptide vial and direct the water stream against the glass wall — not directly onto the powder.
Mix Gently
Swirl the vial gently until the powder is fully dissolved. Never shake. The solution should be clear and colorless.
Store Properly
Refrigerate at Room temperature. 2-3 years.
Storage Temperature
Room temperature
Shelf Life
2-3 years
Important Notes
- •Supplied as powder for oral administration
- •Store in cool, dry place away from light
- •No reconstitution required - not an injectable peptide
Noopept Dosing Calculator
Calculate daily intake, cycle totals, and vials needed with pre-filled protocols →
Noopept Reconstitution Calculator
Calculate concentration, syringe units, and doses per vial with auto-filled values →
Safety & Side Effects
Reported Side Effects
- !Headaches (most common, often dose-dependent)
- !Insomnia or sleep disturbances
- !Irritability or mood changes
- !Nausea or gastrointestinal upset
- !Fatigue or mental exhaustion
- !Dizziness or lightheadedness
- !Increased blood pressure
- !Restlessness or agitation
- !Metallic taste
- !Brain fog (paradoxical effect at high doses)
Potential Interactions
- ⚡May potentiate effects of other nootropics and stimulants
- ⚡Could interact with ADHD medications (amphetamines, methylphenidate)
- ⚡May enhance effects of racetam-class compounds
- ⚡Potential interactions with blood pressure medications
- ⚡Could affect anticoagulant medication effectiveness
Important: Side effects and interactions listed here are compiled from published research and community reports. This is not a complete list. No formal drug interaction studies have been conducted for most research peptides. Always consult a qualified healthcare provider.
Research Studies
The following studies are referenced in this profile. PubMed IDs are provided where available for independent verification.
Noopept and its active metabolite cycloprolylglycine improve memory formation and retrieval
Demonstrated Noopept's superior memory-enhancing effects compared to piracetam, with active metabolite identification and mechanism elucidation.
Neuroprotective and cognition-enhancing effects of Noopept in experimental models
Showed neuroprotective effects against glutamate excitotoxicity and cognitive improvements in animal models of brain damage.
AMPA receptor modulation by Noopept and related compounds
Identified AMPA receptor positive allosteric modulation as a primary mechanism underlying Noopept's cognitive effects.
Clinical efficacy of Noopept in mild cognitive impairment
Human clinical trial demonstrating cognitive improvements in patients with mild cognitive impairment over 56 days of treatment.
Note: This is not an exhaustive list of all published research. Studies are selected for relevance and quality. Click PubMed IDs to verify sources independently. Inclusion does not imply endorsement of the peptide for any clinical use.
Frequently Asked Questions
Acute effects may be noticed within 15-30 minutes of administration, but optimal cognitive benefits typically develop over 7-14 days of consistent use. The compound has a short half-life but produces lasting metabolites that accumulate with regular dosing.
Noopept is significantly more potent than racetam compounds, requiring doses 100-1000 times smaller for similar effects. However, 'stronger' depends on individual response and specific cognitive goals. Its unique mechanism offers different benefits compared to other nootropic classes.
Noopept can be combined with caffeine, but start with reduced doses of both compounds. The combination may increase stimulation and focus but also raises the risk of jitters, anxiety, or sleep disruption. Monitor your response carefully.
Noopept is 100-1000 times more potent than piracetam and works through AMPA receptor modulation rather than AMPA receptor activation. It also has better bioavailability, shorter half-life, and additional neuroprotective mechanisms through BDNF upregulation.
Cycling is recommended - typically 8-12 weeks on followed by 2-4 weeks off. This prevents potential tolerance development and allows assessment of baseline cognitive function. Continuous use may reduce effectiveness over time.
Headaches are the most common side effect, often indicating acetylcholine depletion or increased brain metabolism demands. Try reducing the dose, ensuring adequate hydration, or adding a choline source like alpha-GPC or CDP-choline.
Sublingual administration may provide faster onset and potentially higher bioavailability by bypassing first-pass liver metabolism. However, oral bioavailability is already very high at 99.7%, so the difference may be minimal for most users.
Research suggests Noopept may improve attention and focus through glutamatergic modulation, but it's not a replacement for ADHD medications. Some users report benefits, but individual responses vary significantly and medical supervision is recommended.
Research & Educational Use Only
All content is for informational and research purposes only. This site does not provide medical advice, diagnosis, or treatment. Consult a qualified healthcare professional before using any peptide or supplement.
The information presented here is compiled from published research studies and is intended for informational purposes only. Individual results may vary. Always consult with a licensed healthcare provider.