Pentadecapeptide
Also known as: PL 14736, BPC Analog, Pentadecapeptide BPC-157 Analog
Pentadecapeptide is a synthetic 15-amino acid peptide derived from body protection compound (BPC) sequences that promotes tissue healing and recovery. Research shows it accelerates wound healing, reduces inflammation, and supports gastric protection through angiogenic and cytoprotective mechanisms.
Pentadecapeptide is a 1419.6 Da research peptide. Pentadecapeptide is a synthetic 15-amino acid peptide derived from body protection compound (BPC) sequences that promotes tissue healing and recovery. Research shows it accelerates wound healing, reduces inflammation, and supports gastric protection through angiogenic and cytoprotective mechanisms.
Also called: PL 14736, BPC Analog, Pentadecapeptide BPC-157 Analog
1419.6
Molecular Weight
Daltons
0
Strong Evidence
benefits
4
Studies Cited
peer-reviewed
200-400
Typical Dose
mcg
Overview
Pentadecapeptide represents an optimized synthetic analog of naturally occurring body protection compounds, specifically engineered to enhance stability and bioactivity. This 15-amino acid sequence activates multiple healing pathways simultaneously, including VEGF upregulation for angiogenesis, nitric oxide modulation for vascular function, and growth factor receptor activation for cellular repair. Unlike its parent compounds, pentadecapeptide demonstrates improved resistance to enzymatic degradation while maintaining potent therapeutic effects across multiple tissue types. The peptide's molecular structure allows for enhanced cellular uptake and targeted delivery to sites of injury or inflammation. Research applications focus primarily on accelerated healing protocols, gastrointestinal protection studies, and musculoskeletal recovery enhancement. Laboratory investigations reveal significant promise for treating conditions ranging from tendon injuries to gastric ulcers through its multi-target therapeutic approach.
Key Takeaways: Pentadecapeptide
- Research doses typically range from 200 to 400 mcg via subcutaneous injection
- 0 benefits with strong evidence, 3 moderate, 4 preliminary
- Half-life: 4-6 hours
- 4 cited research studies in this guide
Mechanism of Action
Pentadecapeptide activates angiogenic pathways through VEGF receptor binding and upregulation of endothelial growth factors. The peptide modulates nitric oxide synthase activity to enhance vascular function and blood flow to healing tissues. It stimulates fibroblast proliferation and collagen synthesis through TGF-β pathway activation. The compound also exhibits cytoprotective effects by stabilizing cellular membranes and reducing oxidative stress markers. Additionally, it promotes gastric mucosa protection through prostaglandin E2 pathway enhancement and gastric acid regulation.
Research Benefits
Pentadecapeptide at a Glance
Pentadecapeptide activates angiogenic pathways through VEGF receptor binding and upregulation of endothelial growth factors.
Accelerated Wound Healing
Moderate EvidenceSignificantly increases wound closure rates through enhanced angiogenesis and collagen deposition, with studies showing 40-60% faster healing compared to controls.
Gastric Protection
Moderate EvidenceProtects gastric mucosa from ulceration and promotes healing of existing gastric lesions through enhanced prostaglandin production and acid regulation.
Anti-inflammatory Effects
Moderate EvidenceReduces inflammatory markers including TNF-α and IL-1β while promoting anti-inflammatory cytokine production in injured tissues.
Tendon and Ligament Repair
PreliminaryPromotes tendon healing by increasing collagen synthesis and tensile strength, particularly effective for Achilles tendon and other connective tissue injuries.
Vascular Protection
PreliminaryEnhances endothelial function and protects blood vessels from damage through nitric oxide modulation and antioxidant effects.
Muscle Recovery
PreliminaryAccelerates muscle fiber regeneration and reduces exercise-induced damage markers when administered post-exercise in research models.
Bone Healing Enhancement
PreliminaryStimulates osteoblast activity and bone formation, potentially accelerating fracture healing through growth factor activation.
Research Dosing Protocols
Research Purposes Only: All content is for informational and research purposes only. This site does not provide medical advice, diagnosis, or treatment. Consult a qualified healthcare professional before using any peptide or supplement.
| Research Protocol | Dose Range | Route |
|---|---|---|
| General healing research | 200–400 mcg | subcutaneous injection |
| Gastric protection studies | 10–50 mcg/kg | oral administration |
| Tendon repair research | 2.5–5 mcg/kg | local injection |
| Inflammatory response studies | 100–300 mcg | intraperitoneal injection |
Frequency
Once or twice daily
Timing
Administration 30 minutes before meals for gastric studies, post-injury for healing research
Cycle Length
2-8 weeks depending on research protocol
Research Notes
- 1Research purposes only - not approved for human therapeutic use
- 2Local injection may provide enhanced effects for localized injuries
- 3Oral bioavailability allows for gastric protection studies
- 4Dosing should be adjusted based on body weight in animal models
Reconstitution Guide
Standard Reconstitution
Vial Size
2 mg
Bacteriostatic Water
2 mL
Concentration
10 mcg
per 0.1 mL (10 units)
Step-by-Step Guide
Gather Materials
Pentadecapeptide vial, bacteriostatic water, alcohol swabs, insulin syringes.
Equilibrate Temperature
Remove the vial from storage and allow it to reach room temperature (5-10 minutes).
Sanitize
Swab the rubber stopper of both the peptide vial and bacteriostatic water vial with alcohol.
Draw Water
Draw 2 mL of bacteriostatic water into a syringe.
Add Water to Vial
Insert the needle into the peptide vial and direct the water stream against the glass wall — not directly onto the powder.
Mix Gently
Swirl the vial gently until the powder is fully dissolved. Never shake. The solution should be clear and colorless.
Store Properly
Refrigerate at 2-8°C (refrigerated). 6 months reconstituted, 2 years lyophilized.
Storage Temperature
2-8°C (refrigerated)
Shelf Life
6 months reconstituted, 2 years lyophilized
Important Notes
- •Use bacteriostatic water for multi-dose vials
- •Gently swirl to dissolve - avoid vigorous shaking
- •Solution should be clear and colorless after reconstitution
- •Store away from light to maintain stability
Pentadecapeptide Dosing Calculator
Calculate daily intake, cycle totals, and vials needed with pre-filled protocols →
Pentadecapeptide Reconstitution Calculator
Calculate concentration, syringe units, and doses per vial with auto-filled values →
Safety & Side Effects
Reported Side Effects
- !Injection site reactions (redness, swelling, irritation)
- !Temporary fatigue or drowsiness
- !Mild gastrointestinal upset
- !Headache in sensitive individuals
- !Potential hypotension due to vasodilation effects
- !Allergic reactions in predisposed subjects
- !Temporary changes in blood glucose levels
- !Possible interactions with blood clotting
- !Mild dizziness from vascular effects
Potential Interactions
- ⚡Blood thinning medications - may enhance anticoagulant effects
- ⚡Antihypertensive drugs - potential additive blood pressure lowering
- ⚡Anti-inflammatory medications - may modify inflammatory response
- ⚡Diabetes medications - could affect glucose metabolism
- ⚡Growth hormone therapies - potential synergistic anabolic effects
Important: Side effects and interactions listed here are compiled from published research and community reports. This is not a complete list. No formal drug interaction studies have been conducted for most research peptides. Always consult a qualified healthcare provider.
Research Studies
The following studies are referenced in this profile. PubMed IDs are provided where available for independent verification.
Gastric Cytoprotection by Stable Gastric Pentadecapeptide BPC 157
Demonstrated significant gastric protective effects against various ulcer-inducing agents with dose-dependent cytoprotective activity.
Healing Effects of Pentadecapeptide BPC 157 in Different Models of Tendon Damage
Showed accelerated tendon healing with improved biomechanical properties and reduced inflammatory response in multiple tendon injury models.
Angiogenic and Wound Healing Potency of Native and Synthetic BPC 157
Confirmed angiogenic properties and enhanced wound healing rates through VEGF pathway activation and endothelial cell proliferation.
Pentadecapeptide BPC 157 and the Cardiovascular System
Comprehensive review of cardiovascular protective effects including endothelial protection and blood vessel healing properties.
Note: This is not an exhaustive list of all published research. Studies are selected for relevance and quality. Click PubMed IDs to verify sources independently. Inclusion does not imply endorsement of the peptide for any clinical use.
Frequently Asked Questions
Pentadecapeptide is primarily researched for accelerated healing applications, gastric protection studies, tendon repair research, and anti-inflammatory investigations. It shows promise for wound healing, ulcer prevention, and tissue regeneration across multiple organ systems.
Pentadecapeptide is an analog of BPC-157 with similar healing properties but potentially enhanced stability and bioavailability. Both peptides share angiogenic and cytoprotective mechanisms, though pentadecapeptide may offer improved oral absorption for gastric studies.
Research doses range from 200-400 mcg for general healing studies via subcutaneous injection, or 10-50 mcg/kg for gastric protection research via oral administration. Dosing varies significantly based on the specific research application and model system.
Yes, pentadecapeptide demonstrates oral bioavailability, making it particularly useful for gastric protection research. Oral administration at 10-50 mcg/kg has shown effectiveness in preventing gastric ulceration in research models.
Initial effects may be observed within 24-48 hours for gastric protection, while tissue healing effects typically become apparent within 3-7 days. Full healing benefits generally require 2-4 weeks of consistent administration in research protocols.
Common side effects include injection site reactions, temporary fatigue, mild gastrointestinal upset, and potential blood pressure changes due to vasodilation. Most effects are mild and transient in research settings.
Yes, PL 14736 is an alternative designation for pentadecapeptide. Both terms refer to the same 15-amino acid synthetic peptide with healing and cytoprotective properties.
Lyophilized peptide should be stored at 2-8°C and can remain stable for up to 2 years. Once reconstituted, it should be refrigerated and used within 6 months for optimal potency.
Research & Educational Use Only
All content is for informational and research purposes only. This site does not provide medical advice, diagnosis, or treatment. Consult a qualified healthcare professional before using any peptide or supplement.
The information presented here is compiled from published research studies and is intended for informational purposes only. Individual results may vary. Always consult with a licensed healthcare provider.