Tesofensine
Tesofensine is a triple monoamine reuptake inhibitor that blocks the reuptake of dopamine, norepinephrine, and serotonin. Originally developed as an anti-obesity medication, it demonstrates significant weight loss effects and potential cognitive enhancement properties.
Tesofensine is a 257.37 g/mol research peptide. Tesofensine is a triple monoamine reuptake inhibitor that blocks the reuptake of dopamine, norepinephrine, and serotonin. Originally developed as an anti-obesity medication, it demonstrates significant weight loss effects and potential cognitive enhancement properties.
257.37 g/mol
Molecular Weight
Daltons
2
Strong Evidence
benefits
3
Studies Cited
peer-reviewed
0.25-1
Typical Dose
mg
Overview
Tesofensine represents a unique pharmacological approach to weight management through its triple mechanism of action. Unlike traditional stimulants that primarily target one neurotransmitter system, tesofensine simultaneously inhibits the reuptake of dopamine, norepinephrine, and serotonin. This triple action creates synergistic effects on appetite suppression, metabolic rate enhancement, and mood regulation. Clinical trials have shown tesofensine produces substantial weight loss in obese patients, with some studies reporting average weight reductions of 10-15% over 24 weeks. The compound also shows promise for cognitive enhancement through its dopaminergic activity, which may improve focus, motivation, and mental clarity. However, tesofensine remains an experimental compound with significant cardiovascular and psychiatric risks that require careful monitoring.
Key Takeaways: Tesofensine
- Strongest evidence supports Tesofensine for significant weight loss and appetite suppression
- Research doses typically range from 0.25 to 1 mg via oral
- 2 benefits with strong evidence, 3 moderate, 1 preliminary
- Half-life: 8-12 hours
- 3 cited research studies in this guide
Mechanism of Action
Tesofensine functions as a triple monoamine reuptake inhibitor, blocking the dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT). This simultaneous inhibition increases synaptic concentrations of all three neurotransmitters. The enhanced dopamine signaling in reward pathways reduces food cravings and increases satiety. Elevated norepinephrine boosts metabolic rate through beta-adrenergic receptor activation and promotes lipolysis. Increased serotonin levels contribute to appetite suppression and mood stabilization. The compound also shows affinity for histamine H3 receptors, which may contribute to its wake-promoting and cognitive effects.
Research Benefits
Tesofensine at a Glance
Tesofensine functions as a triple monoamine reuptake inhibitor, blocking the dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT).
Significant Weight Loss
Strong EvidenceClinical trials demonstrate tesofensine produces dose-dependent weight reduction, with patients losing 6-11% of body weight over 24 weeks compared to placebo. The weight loss occurs through reduced caloric intake and increased energy expenditure.
Appetite Suppression
Strong EvidenceThe compound's action on dopamine and serotonin systems effectively reduces hunger signals and food cravings. Patients report feeling full sooner and experiencing fewer between-meal cravings.
Enhanced Metabolic Rate
Moderate EvidenceNorepinephrine reuptake inhibition increases thermogenesis and metabolic rate by 5-8% above baseline. This effect contributes to weight loss even without changes in physical activity levels.
Mood Enhancement
Moderate EvidenceThe compound's effects on serotonin and dopamine can improve mood and reduce depression-related eating behaviors. Some patients experience antidepressant-like effects during weight loss treatment.
Reduced Food Reward Sensitivity
Moderate EvidenceTesofensine alters brain reward pathways, making high-calorie foods less rewarding and easier to resist. This helps break cycles of emotional and compulsive eating.
Improved Cognitive Function
PreliminaryThrough dopamine enhancement, tesofensine may improve working memory, attention, and executive function. Research subjects report increased mental clarity and focus during treatment periods.
Research Dosing Protocols
Research Purposes Only: All content is for informational and research purposes only. This site does not provide medical advice, diagnosis, or treatment. Consult a qualified healthcare professional before using any peptide or supplement.
| Research Protocol | Dose Range | Route |
|---|---|---|
| Weight loss research | 0.25–1 mg | oral |
| Cognitive enhancement research | 0.25–0.5 mg | oral |
Frequency
Once daily in the morning
Timing
Take with or without food, preferably in the morning to minimize sleep disruption
Cycle Length
Research periods typically 12-24 weeks with medical monitoring
Research Notes
- 1Start with lowest dose and increase gradually
- 2Monitor blood pressure and heart rate closely
- 3Avoid evening administration due to stimulant effects
- 4Regular psychiatric evaluation recommended
- 5Not suitable for individuals with cardiovascular disease
Reconstitution Guide
Standard Reconstitution
Vial Size
0 mg
Bacteriostatic Water
0 mL
Concentration
NaN mcg
per 0.1 mL (10 units)
Step-by-Step Guide
Gather Materials
Tesofensine vial, bacteriostatic water, alcohol swabs, insulin syringes.
Equilibrate Temperature
Remove the vial from storage and allow it to reach room temperature (5-10 minutes).
Sanitize
Swab the rubber stopper of both the peptide vial and bacteriostatic water vial with alcohol.
Draw Water
Draw 0 mL of bacteriostatic water into a syringe.
Add Water to Vial
Insert the needle into the peptide vial and direct the water stream against the glass wall — not directly onto the powder.
Mix Gently
Swirl the vial gently until the powder is fully dissolved. Never shake. The solution should be clear and colorless.
Store Properly
Refrigerate at Room temperature. Available as oral tablets or capsules.
Storage Temperature
Room temperature
Shelf Life
Available as oral tablets or capsules
Important Notes
- •Tesofensine is typically provided in oral formulation
- •Store in cool, dry place away from light
- •Not commonly available as injectable peptide
Tesofensine Dosing Calculator
Calculate daily intake, cycle totals, and vials needed with pre-filled protocols →
Tesofensine Reconstitution Calculator
Calculate concentration, syringe units, and doses per vial with auto-filled values →
Safety & Side Effects
Reported Side Effects
- !Increased heart rate and blood pressure
- !Insomnia and sleep disturbances
- !Dry mouth and constipation
- !Nausea and gastrointestinal upset
- !Headache and dizziness
- !Anxiety and restlessness
- !Mood changes and irritability
- !Decreased appetite leading to malnutrition if extreme
- !Potential for psychological dependence
- !Cardiovascular complications in susceptible individuals
Potential Interactions
- ⚡MAO inhibitors - dangerous hypertensive crisis risk
- ⚡SSRIs and SNRIs - serotonin syndrome potential
- ⚡Stimulant medications - additive cardiovascular effects
- ⚡Blood pressure medications - may reduce effectiveness
- ⚡Antidepressants - complex neurotransmitter interactions
Important: Side effects and interactions listed here are compiled from published research and community reports. This is not a complete list. No formal drug interaction studies have been conducted for most research peptides. Always consult a qualified healthcare provider.
Research Studies
The following studies are referenced in this profile. PubMed IDs are provided where available for independent verification.
Tesofensine, a novel triple monoamine reuptake inhibitor with anti-obesity effects
Phase II clinical trial demonstrating significant weight loss in obese patients treated with tesofensine 0.5-1.0mg daily over 24 weeks, with dose-dependent efficacy and manageable side effect profile.
Effects of tesofensine on appetite and food intake in humans
Clinical study showing tesofensine reduces ad libitum food intake by 20-30% and decreases appetite ratings in overweight subjects compared to placebo.
Cardiovascular safety profile of tesofensine in obesity treatment
Safety analysis of tesofensine clinical trials identifying cardiovascular risks including elevated heart rate and blood pressure, particularly at higher doses.
Note: This is not an exhaustive list of all published research. Studies are selected for relevance and quality. Click PubMed IDs to verify sources independently. Inclusion does not imply endorsement of the peptide for any clinical use.
Frequently Asked Questions
Tesofensine is a triple monoamine reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin reuptake. This increases these neurotransmitters in the brain, leading to reduced appetite, increased metabolic rate, and significant weight loss.
Research studies typically use 0.25-1.0mg daily, with 0.5mg being the most common effective dose. Treatment starts at the lowest dose and increases gradually based on tolerance and response.
Clinical trials show average weight loss of 6-11% of body weight over 24 weeks, with some patients losing up to 15%. Results vary based on starting weight, dose, and individual response.
Common side effects include increased heart rate, elevated blood pressure, insomnia, dry mouth, nausea, and anxiety. Cardiovascular monitoring is essential due to potential heart risks.
Long-term safety data is limited. Current research focuses on 12-24 week treatment periods with medical supervision. Extended use requires careful monitoring of cardiovascular and psychiatric effects.
While primarily studied for weight loss, tesofensine's dopamine effects may improve cognitive function. However, research on cognitive benefits is preliminary and the risks may outweigh benefits for this use.
Tesofensine shows greater weight loss efficacy than many approved medications in clinical trials, but it also carries higher cardiovascular risks. It remains experimental and unavailable commercially.
Tesofensine is not approved by the FDA or EMA for commercial use. It's only available through research chemical suppliers for laboratory research purposes, not human consumption.
Research & Educational Use Only
All content is for informational and research purposes only. This site does not provide medical advice, diagnosis, or treatment. Consult a qualified healthcare professional before using any peptide or supplement.
The information presented here is compiled from published research studies and is intended for informational purposes only. Individual results may vary. Always consult with a licensed healthcare provider.